Are you tired of feeling constant joint pain? Do you want the freedom to be able to move without pain?
Try NuJoints® risk free, with our 30 day money back guarantee! Read below about our customer testimonials!
NuJoints® is a one-of-a-kind, powerful, blend designed not only to support the relief of pain and inflammation of arthritis but promote healing and repair of the joint itself. NuJoints® is the most effective and strongest arthritis relief supplement on the market. There is no supplement on the market as advanced and scientifically proven as NuJoints®. NuJoints® is the next generation of alternative medicine for those suffering from Osteoarthritis, Rheumatoid Arthritis and many other joint problems! It is worlds beyond the standard glucosamine/chondroitin as it quickly supports relief of pain, swelling, inflammation, increased mobility, flexibility and range of motion in sensitive joints. The secret to the highly synergistic effect of combining these potent ingredients is the multiple MOA’s (mechanisms of action). By working together, these amazing ingredients start supporting the joints in just 7 days!
NuJoints® is even more effective when taken with Bio-Sorb® Lecithin which contains phospholipids that drastically increase absorption of the active ingredients an also best when taken with Omega-DHA 500® (the most potent fish oil available) for its extremely potent anti-inflammatory effects, as well as increasing absorption of NuJoints®!*
* This statement has not been evaluated by the Food and Drug Administration. Is is not intended to diagnose, treat, cure, or prevent any disease.
BCM-95® Bio-Curcumin® – BCM-95® is a unique, patented blend that is purified, reconstituted and standardized to enhance the absorption of the Curcuminoids from turmeric root such as curcumin, demethoxy curcumin, and bis demethoxy curcumin. It is unique in that the essential oils of turmeric (including turmerones) are added back to the 95% Curcuminoid mixture after it has been extracted. These oils not only enhance the absorption and effectiveness of the Curcuminoids but also have several benefits of its own such as enhancing the effectiveness of the body’s natural anti-cancer and immune system components. BCM-95® Bio-Curcumin® has been proven to enhance absorption of curcuminoids from its norm of about 50% to as high as 97% and to increase bio-availability to body tissues 6.93 times better than standard curcumin!! Also, studies have proven that BCM-95® Bio-Curcumin® reaches its peak blood concentration in half the time (1 hour vs. over 2 hours) and it stays in the blood and tissues at this high concentration for over twice as long (8 hours), whereas normal 95% curcumin withers out after only 4 hours. Thus the 1000mg dosage in NuJoints® would be equivalent to 6,930mg of normal curcumin 95% extract!
The potent anti-inflammatory, anti-arthritic, anti-allergic, anti-bacterial and anti-tumor activities of the Curcuminoids (often collectively termed curcumin) are scientifically proven! Curcumin is a potent anti-oxidant, and prevents tissue and cell destruction due to free radical activity. It acts as a scavenger of oxygen radicals, hydroxyl radicals, nitric oxide radicals, and others. Hence, it helps to retard and prevent various cardiovascular, viral, and other chronic diseases like arthritis, cancer, Alzheimer’s, dementia, and more by neutralizing existing free radicals. It also protects the brain from lipid peroxidation without affecting the central nervous system. It’s incredible effectiveness for both osteoarthritis and rheumatoid arthritis lies in the various mechanisms of action. It reduces the production of inflammatory cytokines by inhibiting specifically COX-II and 5-LOX including NF Kappa beta and TNF alpha and interleukin-1 beta. Of special note, unlike NSAIDS, curcumin does not cause ulcers and stomach problems but actually strengthens and improves digestion, promotes proper metabolism, normalizes gallbladder function and has a soothing effect on the mucosa of the gut and protects the stomach against excess acid.
A recent study at Baylor University on rheumatoid arthritis patients revealed BCM-95® Bio-Curcumin® at 1000mg/day was not only safe and effective but was surprisingly more effective at alleviating pain than diclofenac sodium (Aleve®). This is in line with other studies showing it more effective than ibuprofen with much less side effects. It also has been shown effective in alleviating chronic pain including neuropathic pain which is one of the most difficult to treat. The study went on to show that BCM-95® significantly decreased or stopped altogether swollen joints, tender joints, overall pain, and pain while dressing and grooming, arising, eating and walking. Results showed that 93% of the patients had a 20% decrease in pain, 73% had a 50% reduction in pain, 33% had a 70% reduction and many experienced total pain relief by continually taking 1000mg per day of BCM-95®. Another clinical study compared a combination of 350mg BCM-95® and 150mg Bospure® twice daily verse 100mg of celecoxib (Celebrex®) twice daily for management of knee osteoarthritis. After 12 weeks, the number of patients with moderate or severe pain dropped by 64.28% in the BCM-95®/Bospure® group compared to only 28.57% in the celecoxib group. The natural combo group showed significant improvement in patients walking over 1000 meters and the percentage of patients reporting severe joint line tenderness decreased from ®85.71% down to only 7.14%!
UC-II® is a standardized, undenatured (native) type-II collagen complex containing 25% undenatured type-II collagen in powder form for use as a dietary supplement (U.S. Patents 5,645,851, 5,637,321, 5,529,876, 5,750,144, 7,083,820, EPO Patent Ep1435906B1 and worldwide patents pending). Other forms of collagen sold as dietary ingredients are denatured and hydrolyzed making it drastically less effective. UC-II® is all-natural, safe, well tolerated and sourced and manufactured in USA. It contains undenatured type-II collagen that triggers the deactivation of the inflammatory process in the joints and helps the body rebuild joint cartilage. Published, clinical research of UC-II® at a 40mg/day dose significantly reduced key parameters for joint pain measurement after 90 days. It reduced WOMAC (Western Ontario McMaster) index score, which measures the difficulty in physical function, stiffness, and pain in the knee by 33%, VAS (Visual Analog Scale) was reduced by 40% and Lequesne score was reduced by 20%. The same research showed that glucosamine 1500mg + 1200mg chondroitin reduced WOMAC, VAS and Lequesne scores by 14%, 15% and 6%, respectively. This is a tremendous improvement and a replacement for glucosamine/chondroitin at only a small 40mg dose and it actually helps rebuild your joints! Legal structure/function claims include: Supports Joint Comfort, Supports Joint Mobility, Supports Joint Flexibility, and Increases Daily Activity.
Results at Harvard University showed UC-II® not only effective in improving symptoms of rheumatoid arthritis but in some cases there was complete remission! IT also significantly improved quality of life, such as reducing pain when ascending stairs, pain at night while in bed, pain climbing up and down stairs and difficulty walking on a flat surface. Another study over just 42 days showed a significant reduction in pain, morning stiffness, and stiffness following periods of rest, resulting in an average decrease in pain of over 26%.
Wear and tear on the joints causes an inflammatory process. Once this inflammation cascade has begun, the joint gets caught in an endless self-repeating cycle that eventually leads to erosion of joint collagen. UC-II® works in the small intestine to help prevent degradation of type II collagen in the joints and support joint cartilage rebuilding. When joint cartilage breaks down, debris consisting of type II collagen is released into the blood where it is recognized by the immune system as “unnatural.” In response, the immune system releases collagen-specific T cells to the site of “injury” where they initiate removal of the debris. Generally, the immune system responds to joint damage only for short periods of time. When the responses continue unabated for weeks and months, joint issues can occur. This uncontrolled inflammatory response leads to painful joints.
- Active epitopes in UC-II® interact with Peyer’s patches (lymphoid tissue) in the small intestine resulting in the release of a second class of collagen-specific, regulatory T cells that migrate to the joint areas and modulate the ongoing local inflammatory response occurring there.
- Through the action of these collagen-specific T cells, the secretion of collagenase enzymes by macrophages that break down the collagen in the joint is vastly slowed.
- These collagen-specific regulatory t cells also slow the production of inflammatory cytokines further modulating joint cartilage erosion.
- As inflammations subside, the imbalance of cartilage turnover appears to shift in favor of normal cartilage rebuilding. Studies have shown that UC-II® supplementation can reduce the incidence and the severity of arthritis after only 6 days!
- With UC-II®, only immune responses against type II collagen are modulated. It does not affect normal immune system function.
- It is extremely safe and non-toxic. Toxicity studies showed an equivalent of over 100x the recommended dose were safe with no adverse events.
- Hyaline cartilage, the type from which UC-II® is derived, covers the ends of bones to form the smooth surface of joints which provides flexibility and support to bones and joints. Type-II is the most abundant structural protein in hyaline cartilage and accounts for 40-45% of the dry weight of cartilage and is responsible for its tensile strength and toughness. Type-II cartilage is composed primarily of the amino acids glycine (30-33%), proline and hydroxyproline (15-30%).
Perluxan® is a proprietary extract of hops cones with a minimum of 30% alpha acids designed to be free of phytoestrogenic and sleep inducing compounds. It is anti-inflammatory, anti-oxidative and inhibits bone resorption. It has a great safety profile and is GI friendly and most importantly it is very fast acting. The primary alpha acid, humulone, is highly specific for COX-2 inhibition and has better free radical scavenging activity and better protection from lipid peroxidation than Vitamin C and Vitamin E. In a recent 14 day study on osteoarthritis pain, a 1000mg/day dosage Perluxan® showed a fast acting effect on mean pain relief and significant improvement over placebo in only 2 hours after the first dose. By week 2, it was shown to clearly help relieve pain during normal daily activities and improve joint mobility as well. The effectiveness was also supported by the extremely limited use of rescue medication in the group taking Perluxan®.
Perluxan® works by selectively inhibiting iNOS, PGE2, and COX-2, key pathways in the management of pain and inflammation. It is a very potent and specific inhibitor of the TNF-alpha-dependent COX-2 induction, which decreased release of PGE2 thus inhibiting bone resorption (a process by which the body breaks down bone for other uses). Humulone was shown to produce COX-2 inhibition comparable to 400mg ibuprofen for over 9 hours but had significant COX-1 sparing activity relative to ibuprofen, a major benefit for the gastrointestinal system. Earlier studies showed Perluxan® more potent than aspirin, diclofenac, ibuprofen or naproxen and a higher degree of COX-2 selectivity than newer NSAIDS such as celecoxib, etodolac, meloxicam and rofecoxib. Basically this means it highly inhibits the COX-2 enzyme, which causes pain and inflammation, but does not inhibit COX-1 (the enzyme that protects your GI system) whereas all the NSAIDS, even the newer ones, have shown to do so in repeated tests. So you do not have to worry about ulcers with Perluxan®!
Bospure® - is a patented form of Boswellia Serrata specially formulated to contain 70% total organic acids, and 40% total Boswellic Acids consisting of greater than 10% AKBA (the primary constituent) and also Acetyl-alpha-Boswellic Acid, Acetyl-beta-Boswellic Acid but formulated to contain zero beta-Boswellic Acid (the one that may actually cause inflammation). AKBA (Acetyl-11-Keto-beta-Boswellic Acid) is the most active compound with several activities and mechanisms of action such as:
- 5-LOX (5-lipoxygenase) inhibition
- Human Leukocyte Elastase Inhibition
- Topoisomerase Inhibition
- Calcium Mobilization
- MAP Kinase Activation
- Caspase Activation
- IKK Inhibition leading to inhibition of constitutively activated NFkB
The key enzyme in the conversion of Arachidonic Acid to Leukotrienes B5 (LTB5) is 5-LOX. Inhibition of 5-LOX thus assumes special significance when it comes to chronic inflammatory disorders. Much lower concentrations of Bospure® as compared to typical Boswellia Serrata 65% extract are needed to inhibit 5-LOX and 15-LOX. Thus it is much more effective even at a smaller dosage. As mentioned above, Bospure® 150mg was combined with BCM-95® 350mg twice daily (NuJoints® contains 250mg and 500mg, respectively, in its twice daily dosage) and shown to be highly effective even when compared to celocoxib!
Hyaluronic Acid is a naturally occurring polysaccharide that belongs to the glycosaminoglycan family and consists of a basic unit of two sugars, glucuronic acid and N-acetyl-glucosamine. It is a natural component of connective tissue, including the skin; it is also found in joint fluid, and it plays a role in providing volume to skin by retaining water. It became popular in cosmetics for aging skin and wrinkles. It is used orally or injected into the joint for arthritis, and has been used successfully as an injection to decrease the depth of facial wrinkles for up to a year. It forms a thick and flexible solution in water and functions as a tissue or joint lubricant, which plays an important role in modulating the interactions between adjacent tissues.
Hyaluronic Acid (HA) is an important component of articular (joint) cartilage, where it is present at the ends of bones as a coat around each cell (chondrocyte). Hyaluronic aggregates form and absorb water which accounts for the resilience of cartilage (its resistance to compression). It also increases the viscosity of synovial fluid between joint, providing a more effective cushion. HA has also been shown to decrease the swelling and inflammation of the synovium, the thin membrane on the inside of joints. HA in human cartilage decreases with age. Intrajoint HA injections have shown effective in the treatment of osteoarthritis, but oral HA was found to enhance several markers of quality of life, such as pain and physical functioning in adults with arthritis of the knee. Several positive changes were seen at the 4 week point and even more at the 8 week conclusion using just 48mg/day. Statistically significant changes were seen for bodily pain, social functioning and physical component. NuJoints® contains a double dose of 180mg of 95% hyaluronic acid in the initial loading phase of 3 capsules twice daily.
Bromelain 2400 GDU – Bromelain is an enzyme derived from pineapple that shows promise for treating the symptoms of inflammation associated with arthritis without causing the GI side-effects typical of NSAIDS. It is used here for its synergistic anti-inflammatory effect and its possible effectiveness in increasing the absorption of curcuminoids, collagen and hyaluronic acid.
Ginger 5% ext. - The anti-inflammatory properties of ginger have been known and valued for centuries. The original discovery of ginger's inhibitory effects on prostaglandin biosynthesis in the early 1970s has been repeatedly confirmed. This discovery identified ginger as an herbal medicinal product that shares pharmacological properties with NSAIDS. One of the features of inflammation is increased oxygenation of arachidonic acid which is metabolized by two enzymatic pathways--the cyclooxygenase (COX) and the 5-lipoxygenase (5-LOX)--leading to the production of prostaglandins and leukotrienes respectively. Amongst the COX products, PGE2 and amongst the 5-LOX products, LTB4 are considered the most important mediators of inflammation Ginger suppresses prostaglandin synthesis through inhibition of cyclooxygenase-2 (COX-2). An important extension of this was the observation that ginger also suppresses leukotriene biosynthesis by inhibiting 5-lipoxygenase (5-LOX). It is now well established that dual inhibitors of COX-2 and 5-LOX enzymes provide a much better therapeutic profile and have fewer side effects than NSAIDS.
In a recent study of 247 patients with osteoarthritis, the percentage of responders experiencing a reduction in knee pain on standing was 63%. Analysis of the secondary efficacy variables revealed a consistently significant response when analyzing mean values such as reduction in knee pain on standing, reduction in knee pain after walking 50 feet, and reduction in the Western Ontario and McMaster Universities osteoarthritis composite index. In another significant study, 56 patients (28 with rheumatoid arthritis, 18 with osteoarthritis and 10 with muscular discomfort) used standardized ginger extract against their afflictions. Amongst the arthritis patients more than three-quarters experienced, to varying degrees, relief in pain and swelling. All the patients with muscular discomfort experienced relief in pain. None of the patients reported adverse effects during the period of ginger consumption which ranged from 3 months to 2.5 years.
Ascorbyl Palmitate – the fat soluble form of Vitamin C is used as a preservative to maintain freshness and to possibly provide better absorption of active ingredients. It also has anti-oxidant and anti-inflammatory effects of its own.
Manganese – is an essential mineral that supports many enzyme controlled reactions. In fact, it is required for the enzyme glycosyltransferease, which is essential for the formation of collagen, GAG’s and proteoglycans that are all components of cartilage. A lack of manganese can lead to inefficient production of GAGs in the joints
Bioperene® - is a registered trademark and patent product of the Sabinsa Corporation. Bioperene® is an extract of black pepper (piper nigrum) standardized to contain a minimum of 95% piperine. It has been shown in numerous studies to enhance the absorption of curcumin by up to 2000%! It has also been shown to possibly increase the absorption of the other natural ingredients in NuJoints®.
- Initially, take 3 capsules twice daily during meals, (yes, actually eat half your meal, take the 3 capsules, then finish your meal) as a loading dose. Take this dosage for 3 weeks to 3 months –basically whatever duration is needed until your joints feel great again! Then you may decrease to a maintenance dose of 2 to 3 capsules daily to save money, if so desired. The severity of your particular situation will determine the length of time you will need to take the loading dose to get it under control. Very severe situations may necessitate that you continue taking 3 capsules twice daily permanently. The NuJoints® Stack, which consists Taking three (3) NuJoints® capsules, one (1) Bio-Sorb® Lecithin softgel, and one (1) Omega-DHA 500® softgel during each meal twice daily drastically enhances absorption and maximizes overall effectiveness for those severe cases! Take control of your health and start living again!
NO RISK! Complete 100% Money-Back Guarantee!!
-We simply ask that you take the loading dose exactly as directed for 30 days and if you are not 100% satisfied, we will gladly refund your entire purchase price including shipping! Due to our tremendous success rate, we are that confident you will see results!